It was the birthplace of St. Francis, who founded the Franciscan religious order in the town in 1208, and St. Clare (Chiara d’Offreducci), the founder of the Poor Sisters, which later became the Order of Poor Clares after her death. The 19th-century Saint Gabriel of Our Lady of Sorrows was also born in Assisi.
During his life, Frank was renowned for having eschewed wealth and lived in poverty as a humble man. It strikes me as odd that within two years of his death, a huge basilica was erected in his memory. I wonder what he would have made of that.